The albumin/globulin (A/G) ratio is a calculated value derived from the levels of albumin and globulin proteins in blood serum. It is obtained by dividing the albumin concentration by the globulin concentration. For example, if a blood test indicates an albumin level of 4.0 g/dL and a globulin level of 2.0 g/dL, the resultant ratio would be 2.0. Variations from the typical reference range can indicate underlying medical conditions.
Assessment of this ratio aids in the evaluation of liver function, kidney function, and nutritional status. Significant deviations from the normal range can be suggestive of liver disease (such as cirrhosis or hepatitis), kidney disorders (such as nephrotic syndrome), or certain autoimmune diseases. Analyzing this ratio provides clinicians with a valuable, readily available indicator, aiding in the diagnostic process and in monitoring the progression of various diseases.